癌症是一种复杂的疾病，具有重大的社会和经济影响。高通量分子测定的进步以及进行高质量多摩斯测量的成本降低，通过机器学习促进了见解。先前的研究表明，使用多个OMIC预测生存和分层癌症患者的希望。在本文中，我们开发了一种有监督的自动编码器（SAE）模型，用于基于生存的多摩变集成，该模型在以前的工作中改进，并报告一种具体的监督自动编码器模型（CSAE），该模型（CSAE）也使用功能选择来共同重建输入功能。作为预测生存。我们的实验表明，我们的模型表现优于或与一些最常用的基线相提并论，同时提供更好的生存分离（SAE）或更容易解释（CSAE）。我们还对我们的模型进行了特征选择稳定性分析，并注意到与通常与生存有关的特征存在幂律关系。该项目的代码可在以下网址获得：https：//github.com/phcavelar/coxae

Machine learning models are typically evaluated by computing similarity with reference annotations and trained by maximizing similarity with such. Especially in the bio-medical domain, annotations are subjective and suffer from low inter- and intra-rater reliability. Since annotations only reflect the annotation entity's interpretation of the real world, this can lead to sub-optimal predictions even though the model achieves high similarity scores. Here, the theoretical concept of Peak Ground Truth (PGT) is introduced. PGT marks the point beyond which an increase in similarity with the reference annotation stops translating to better Real World Model Performance (RWMP). Additionally, a quantitative technique to approximate PGT by computing inter- and intra-rater reliability is proposed. Finally, three categories of PGT-aware strategies to evaluate and improve model performance are reviewed.

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

We test grip strength and shock absorption properties of various granular material in granular jamming robotic components. The granular material comprises a range of natural, manufactured, and 3D printed material encompassing a wide range of shapes, sizes, and Shore hardness. Two main experiments are considered, both representing compelling use cases for granular jamming in soft robotics. The first experiment measures grip strength (retention force measured in Newtons) when we fill a latex balloon with the chosen grain type and use it as a granular jamming gripper to pick up a range of test objects. The second experiment measures shock absorption properties recorded by an Inertial Measurement Unit which is suspended in an envelope of granular material and dropped from a set height. Our results highlight a range of shape, size and softness effects, including that grain deformability is a key determinant of grip strength, and interestingly, that larger grain sizes in 3D printed grains create better shock absorbing materials.

Accurate uncertainty measurement is a key step to building robust and reliable machine learning systems. Conformal prediction is a distribution-free uncertainty quantification algorithm popular for its ease of implementation, statistical coverage guarantees, and versatility for underlying forecasters. However, existing conformal prediction algorithms for time series are limited to single-step prediction without considering the temporal dependency. In this paper we propose a Copula Conformal Prediction algorithm for multivariate, multi-step Time Series forecasting, CopulaCPTS. On several synthetic and real-world multivariate time series datasets, we show that CopulaCPTS produces more calibrated and sharp confidence intervals for multi-step prediction tasks than existing techniques.

For conceptual design, engineers rely on conventional iterative (often manual) techniques. Emerging parametric models facilitate design space exploration based on quantifiable performance metrics, yet remain time-consuming and computationally expensive. Pure optimisation methods, however, ignore qualitative aspects (e.g. aesthetics or construction methods). This paper provides a performance-driven design exploration framework to augment the human designer through a Conditional Variational Autoencoder (CVAE), which serves as forward performance predictor for given design features as well as an inverse design feature predictor conditioned on a set of performance requests. The CVAE is trained on 18'000 synthetically generated instances of a pedestrian bridge in Switzerland. Sensitivity analysis is employed for explainability and informing designers about (i) relations of the model between features and/or performances and (ii) structural improvements under user-defined objectives. A case study proved our framework's potential to serve as a future co-pilot for conceptual design studies of pedestrian bridges and beyond.

The 1$^{\text{st}}$ Workshop on Maritime Computer Vision (MaCVi) 2023 focused on maritime computer vision for Unmanned Aerial Vehicles (UAV) and Unmanned Surface Vehicle (USV), and organized several subchallenges in this domain: (i) UAV-based Maritime Object Detection, (ii) UAV-based Maritime Object Tracking, (iii) USV-based Maritime Obstacle Segmentation and (iv) USV-based Maritime Obstacle Detection. The subchallenges were based on the SeaDronesSee and MODS benchmarks. This report summarizes the main findings of the individual subchallenges and introduces a new benchmark, called SeaDronesSee Object Detection v2, which extends the previous benchmark by including more classes and footage. We provide statistical and qualitative analyses, and assess trends in the best-performing methodologies of over 130 submissions. The methods are summarized in the appendix. The datasets, evaluation code and the leaderboard are publicly available at https://seadronessee.cs.uni-tuebingen.de/macvi.

Many high-level skills that are required for computer vision tasks, such as parsing questions, comparing and contrasting semantics, and writing descriptions, are also required in other domains such as natural language processing. In this paper, we ask whether this makes it possible to learn those skills from text data and then use them to complete vision tasks without ever training on visual training data. Key to our approach is exploiting the joint embedding space of contrastively trained vision and language encoders. In practice, there can be systematic differences between embedding spaces for different modalities in contrastive models, and we analyze how these differences affect our approach and study a variety of strategies to mitigate this concern. We produce models using only text training data on three tasks: image captioning, visual entailment and visual question answering, and evaluate them on standard benchmarks using images. We find that this kind of transfer is possible and results in only a small drop in performance relative to models trained on images. We also showcase a variety of stylistic image captioning models that were trained using no image data and no human-curated language data, but instead text data from books, the web, or language models.

We describe the AGReE system, which takes user-submitted passages as input and automatically generates grammar practice exercises that can be completed while reading. Multiple-choice practice items are generated for a variety of different grammar constructs: punctuation, articles, conjunctions, pronouns, prepositions, verbs, and nouns. We also conducted a large-scale human evaluation with around 4,500 multiple-choice practice items. We notice for 95% of items, a majority of raters out of five were able to identify the correct answer and for 85% of cases, raters agree that there is only one correct answer among the choices. Finally, the error analysis shows that raters made the most mistakes for punctuation and conjunctions.

机器学习方法越来越广泛地用于医疗保健，运输和金融等高危环境中。在这些环境中，重要的是，模型要产生校准的不确定性以反映其自信并避免失败。在本文中，我们调查了有关深度学习的不确定性定量（UQ）的最新著作，特别是针对其数学属性和广泛适用性的无分配保形方法。我们将涵盖共形方法的理论保证，引入在时空数据的背景下提高UQ的校准和效率的技术，并讨论UQ在安全决策中的作用。